How Do People React to COVID-19 Vaccination? A Corpus-Based Study of Macau Netizens' Online Comments

This study draws on corpus methodology to investigate people's reactions to COVID-19 vaccination using the data of Macau netizens' comments on a YouTube channel. Four main topics under discussion were identified based on the word lists. Meanwhile, people were concerned about the activity of vaccines and were also engaged in heated debates on both domestic and foreign vaccines according to the collocation of "疫苗” yìmiáo (vaccine). The discussion topics and concerns varied along with time, evidenced by the results of word lists and collocates of each month. It is also noticeable that some misinformation on vaccines burgeoned and faded before and after the mass vaccination of Macau residents. The supportive voices for the (Chinese) vaccines were building up their momentum over time. This phenomenon lends support to the effective persuasion of gain-framed messages in advocating safe behaviour based on Prospect Theory. Our research has revealed that the corpus-based study of online comments can be leveraged to uncover people's social behaviour in the pandemic context. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

[Research progress on the relationship between low-density neutrophils and infectious diseases]

Neutrophils play an important role in infectious diseases by clearing pathogens in the early stages of the disease and damaging the surrounding tissues along with the disease progress. Low-density neutrophils (LDNs) are a crucial and distinct subpopulation of neutrophils. They are a mixture of activated and degranulated normal mature neutrophils and a considerable number of immature neutrophils prematurely released from the bone marrow. Additionally, they may be involved in the occurrence and development of diseases through the changes in phagocytosis, the generation of reactive oxygen species (ROS), the enhancement of the ability to produce neutrophils extracellular traps and immunosuppression. We summarizes the role of LDNs in the pathogenesis and their correlation with the severity of infectious diseases such as COVID-19, severe fever with thrombocytopenia syndrome (SFTS), AIDS, and tuberculosis.

The efficiency of COVID-19 vaccines among taiwanese patients with varied comorbidities

Background/Aims: The global pandemic of COVID-19 has caused tremendous loss of human life since 2019. Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the best policies to control the pandemic. The vaccination efficacy in Taiwanese patients with different comorbidities is elusive and to be explored. Method(s): Uninfected subjects who received 3-doses of mRNA vaccines (Moderna, BioNTech), non-replicating viral vector-based vaccines (AstraZeneca, AZ) or protein subunit vaccines (Medigen COVID-19 vaccine, MVC) were prospectively enrolled. SARSCoV2- IgG spike antibody level was determined (Abbott [SARS-CoV- 2 IgG II]) within 3 months after the last dose of vaccination. Charlson Comorbidity Index (CCI) was applied to disclose the association of vaccine titer and underlying comorbidities. Result(s): A total of 824 subjects were enrolled in the current study. The mean age was 58.9 years and males accounted for 48.7% of the population. The proportion of CCI with 0-1, 2-3 and>4 was 52.8% (n = 435), 31.3% (n = 258) and 15.9% (n = 131), respectively. The most commonly used vaccination combination was AZ-AZ-Moderna (39.2%), followed by Moderna-Moderna-Moderna (27.8%) and AZAZ- BioNTech (14.7%), respectively. The mean vaccination titer was 3.11 log BAU/mL after a median 48 days of the 3rd dose. Subjects of male gender, lower body mass index, chronic kidney disease, higher CCI, and receiving AZ-AZ based vaccination were likely to have a lower titer of antibody. There was a decreasing trend of antibody titer with the increase of CCT (trend P<0.001). Linear regression analysis revealed that AZ-AZ-based vaccination (beta: 0.341, 95% confidence intervals [CI]: 0.144, 0.21, P<0.001) and higher CCI (beta: - 0.055, CI: - 0.096, - 0.014, P = 0.009) independently correlated with low IgG spike antibody levels. Conclusion(s): Patients with more comorbidities had a poor response to 3 doses of COVID-19 vaccination. Further studies are warranted to clarify the efficacy of booster vaccination in the population. The vaccine titer did not differ between patient with or without chronic liver disease.

Implications of the Improvement in Atmospheric Fine Particles: A Case Study of COVID-19 Pandemic in Northern Taiwan

The outbreak of COVID-19 pandemic in northern Taiwan led to the implementation of Level 3 alert measures during 2021 and thereby impacted the air quality significantly, which provided an unprecedented opportunity to better understand the control strategies on air pollutants in the future. This study investigated the variations in sources, chemical characteristics and human health risks of PM2.5 comprehensively. The PM2.5 mass concentrations decreased from pre-alert to Level 3 alert by 49.4%, and the inorganic ions, i.e., NH4+, NO3- and SO42-, dropped even more by 71%, 90% and 52%, respectively. Nonetheless, organic matter (OM) and elemental carbon (EC) simply decreased by 36% and 13%, which caused the chemical composition of PM2.5 to change so that the carbonaceous matter in PM2.5 dominated instead of the inorganic ions. Correlation-based hierarchical clustering analysis further showed that PM2.5 was clustered with carbonaceous matter during the Level 3 alert, while that clustered with inorganic ions during both pre-alert and post-alert periods. Moreover, 6 sources of PM2.5 were identified by positive matrix factorization (PMF), in which secondary nitrate (i.e., aging traffic aerosols) exhibited the most significant decrease and yet primary traffic-related emissions, dominated by carbonaceous matter, changed insignificantly. This implied that secondary traffic-related aerosols could be easily controlled when traffic volume declined, while primary traffic source needs more efforts in the future, especially for the reduction of carbonaceous matter. Therefore, cleaner energy for vehicles is still needed. Assessments of both carcinogenic risk and non-carcinogenic risk induced by the trace elements in PM2.5 showed insignificant decrease, which can be attributed to the factories that did not shut down during Level 3 alert. This study serves as a metric to underpin the mitigation strategies of air pollution in the future and highlights the importance of carbonaceous matter for the reduction in PM2.5.

Cooperate with community health centers to eliminate HCV in low prevalence region of South China

Background: Shenzhen, a city of immigrants in South China, has a low HCV incidence rate of 19.47 per 100,000. To eliminate HCV in this low prevalence region, it may be efficiency to collaborate with the communities to screen HCV in high risk population. There are 849 Community Health Centers up to now in Shenzhen. The study aimed to evaluate the model of HCV elimination in high-risk population with Community Health Centers. Method(s): The Shenzhen Medical Association assigned hepatologists to educate Primary Care Physicians (PCPs) of 13 Community Health Centers in Bao'an District from 2021.6-2022.6. The PCPs need to take HCV knowledge tests before and after the training. Only when all the questions are answered correctly can the test be passed. Then they recommend the high risk population, e.g., PWID, pricking wound, iatrogenic exposure, to do the HCV antibody test and transfer the patients with HCV-Ab (+) to the hepatologist of Shenzhen Bao'an People's Hospital. Result(s): 151 PCPs participated in HCV knowledge education, the pass rate improved from 15.2% to 53.8% after the training. The high risk population screening number in Community Health Centers improved from 192 (a year before) to 300, even affected by the lockdown of COVID-19. The HCV antibody positive rate in high risk population is 4% (12/300), higher than the hospital population (0.8%, Shenzhen Bao'an People's Hospital), the blood donor (0.3%, Shenzhen Blood Center). The HCV-Ab positive patients in communities transferred to Shenzhen Bao'an People's Hospital, where the rate of DAA treatment is improved from 36.6% (a year before) to 64.1%. Conclusion(s): It is an efficient way to achieve HCV elimination earlier to screening in high risk population through PCPs in low prevalence region. Expanding this model to other Community Health Centers in Shenzhen may accelerate HCV elimination. (Figure Presented).

[Research progress on the relationship between low-density neutrophils and infectious diseases]

Neutrophils play an important role in infectious diseases by clearing pathogens in the early stages of the disease and damaging the surrounding tissues along with the disease progress. Low-density neutrophils (LDNs) are a crucial and distinct subpopulation of neutrophils. They are a mixture of activated and degranulated normal mature neutrophils and a considerable number of immature neutrophils prematurely released from the bone marrow. Additionally, they may be involved in the occurrence and development of diseases through the changes in phagocytosis, the generation of reactive oxygen species (ROS), the enhancement of the ability to produce neutrophils extracellular traps and immunosuppression. We summarizes the role of LDNs in the pathogenesis and their correlation with the severity of infectious diseases such as COVID-19, severe fever with thrombocytopenia syndrome (SFTS), AIDS, and tuberculosis.

In the context of the COVID-19 pandemic, can the development of coastal ecological resources create a safe leisure and tourism environment, maintain ecology, and promote economic development in villages?

Context and aims. The purpose of the study was to examine the impact of environmental development in the seashore waters of Maluan Bay on the current situation of sustainable development of coastal villages. Methods. We used SPSS statistical software (ver. 26.0) to analyse the data with statistical verification, Student's t-test and ANOVA, the used the inverview method to solicit opinions on the questionnarie results, and, finally, conducted multivariate inspection and analysis to explore the results. Key results. The development of seashore waters can effectively enhance people's positive perceptions of the current economic, social, environmental and coastal ecological development, and increase their willingness to revisit and purchase property. Also, the insufficient number of security guards in villages can be improved, the environmental awareness of residents and their willingness to participate in decision-making can be enhanced. Conclusions and implications. Providing tourists with better tourism facilities, transportation, hotel and restaurant management and planning will increase leisure opportunities and solve environmental and waste problems such as in this scenic location. It will help achieve the goal of sustainable circular economy of water.

Performance optimization of water cycle algorithm for multilevel lupus nephritis image segmentation

Lupus nephritis (LN) is one of the most common and serious clinical manifestations of systemic lupus erythe-matosus (SLE), which causes serious damage to the kidneys of patients. To effectively assist the pathological diagnosis of LN, many researchers utilize a scheme combining multi-threshold image segmentation (MIS) with metaheuristic algorithms (MAs) to classify LN. However, traditional MAs-based MIS methods tend to fall into local optima in the segmentation process and find it difficult to obtain the optimal threshold set. Aiming at this problem, this paper proposes an improved water cycle algorithm (SCWCA) and applies it to the MIS method to generate an SCWCA-based MIS method. Besides, this MIS method uses a non-local means 2D histogram to represent the image information and utilizes Renyi's entropy as the fitness function. First, SCWCA adds a sine initialization mechanism (SS) in the initial stage of the original WCA to generate the initial solution to improve the population quality. Second, the covariance matrix adaptation evolution strategy (CMA-ES) is applied in the population location update stage of WCA to mine high-quality population information. To validate the excellent performance of the SCWCA-based MIS method, the comparative experiment between some peers and SCWCA was carried out first. The experimental results show that the solution of SCWCA was closer to the global optimal solution and can effectively deal with the local optimal problems. In addition, the segmentation experiments of the SCWCA-based MIS method and other equivalent methods on LN images showed that the former can obtain higher-quality segmented LN images.

Antiviral agents for COVID-19.

In December 2019, the endemic of COVID-19 broke out in Wuhan, China. The disease is highly contagious and quickly spreads at home and abroad, causing great concern. However, there are no definite effective antiviral drugs in clinical use. Given the urgency of the COVID-19 outbreak, based on the diagnosis and treatment recommendation and relavant researches, this article describes the optional antiviral drugs such as remdesivir, oseltamivir, arbidol, lopinavir/ritonavir, ribavirin, and interferon-alpha to provide a reference for treatment of COVID-19.Copyright © 2020 by the Chinese Medical Association.

Smart Mirror Activated by User's Face Recognition with Simulation of Artificial Intelligence Classifier

This paper presented a simple and easy-To-use intelligent mirror with the activated function by face recognition. Firstly, the function of face recognition was realized by the OpenMV platform, and the recognition information was transmitted to the main controller, i.e., Loongson 1C Zhilong development board. The main controller connected to the Django server through the distant communication function of ESP8266 module. The user's schedules were acquisitioned by such a communication pathway and analyzed by the main controller. Finally, the recognized user's business or traveling schedule was shown on a screen located in the rear of a semitransparent mirror. For strangers of this smart mirror, the successful rate of strangers was 100%. For the user, the successful rate of strangers was 90% and accuracy of user's recognition was 100% in 120 times of tests. Furthermore, Adaptive Neuro Fuzzy Inference System supports a nice performance for Automatic classification in computer simulation. The COVID-19 pandemic is still threatening human beings. A smart mirror with the function of face recognition activation is a non-Touching solution for avoiding the infections to support an idea for elevating human health. © 2023 Global IT Research Institute (GiRI).

[Research progress on the relationship between low-density neutrophils and infectious diseases]

Neutrophils play an important role in infectious diseases by clearing pathogens in the early stages of the disease and damaging the surrounding tissues along with the disease progress. Low-density neutrophils (LDNs) are a crucial and distinct subpopulation of neutrophils. They are a mixture of activated and degranulated normal mature neutrophils and a considerable number of immature neutrophils prematurely released from the bone marrow. Additionally, they may be involved in the occurrence and development of diseases through the changes in phagocytosis, the generation of reactive oxygen species (ROS), the enhancement of the ability to produce neutrophils extracellular traps and immunosuppression. We summarizes the role of LDNs in the pathogenesis and their correlation with the severity of infectious diseases such as COVID-19, severe fever with thrombocytopenia syndrome (SFTS), AIDS, and tuberculosis.

How students view online knowledge: Epistemic beliefs, self-regulated learning and academic misconduct

The use of the internet in education has been greatly encouraged by the COVID-19 epidemic. Studying students' internet-specific epistemic beliefs (ISEB) and possible correlates would benefit online teaching and learning. However, little research has been conducted in this field. Therefore, we investigated the current status of ISEB among college students and considered the impact of self-regulated learning (SRL) and e-academic dishonesty (e-AD) on ISEB. A survey research method and convenience sampling were employed. A total of 538 Chinese college students completed the self-reported questionnaire. Our results indicate that although no significant differences were found in ISEB in terms of gender and academic major, students with different backgrounds also differed in e-AD experience and SRL. Three dimensions of ISEB were negatively correlated with SRL, while one had a significant positive correlation. In addition, the latter dimension of ISEB was negatively correlated with e-AD. Finally, SRL and e-AD jointly significantly predicted students' different ISEB, with explanatory power ranging from 14% to 36%. Study techniques of SRL were common predictors that could negatively predict the certainty, simplicity, and source of ISEB and positively predict justification. Based on the results, specific methods for schools, teachers and librarians to enhance students' ISEB are provided. © 2023

Some considerations in dermatology teaching about national public health emergencies.

Recently, the 2019 novel coronavirus has rapidly spread throughout China. The medical staff at dermatology departments of some hospitals in Hubei province also participated in the fight against coronavirus disease 2019. However, many problems emerged during this period. Some medical staff at dermatology departments lacked abilities to deal with emergencies, self-protect, and to conduct surveys on skin diseases occurring in this period. In this article, the authors highlight common problems in and give advice on dermatology teaching about national public health emergencies to healthcare workers, undergraduate students, graduate students and senior residents, hoping that healthcare workers at dermatology departments will calmly deal with public health emergencies in the future.Copyright © 2020 by the Chinese Medical Association.

The Behavioral Intention of Hospitals to Promote Sustainable Development of Green Healthcare from the Perspective of Organizational Stakeholders during the COVID-19 Epidemic: A Case Study of Hospitals in Taiwan

When the World Health Organization (WHO) analyzed the culprits of global warming, it was found that in developed countries with relatively few high-polluting heavy industries, the medical sector is one of the sources of high-density carbon emissions. Therefore, the medical industry has a noticeable impact on the environment. Amid the current COVID-19 epidemic, this study adopts the theory of planned behavior (TPB), widely used in decision-making science. We selected a regional teaching hospital with 339 employees in Taiwan to obtain valid questionnaire data. We explore the comparative analysis of different intra-organizational stakeholders' "attitudes,” "subjective norms,” and "perceived behavioral control” on the hospital's behavioral intention to promote green healthcare. The results show that the TPB model has reliable explanatory power. All three factors have a positive and significant effect on promoting green hospital behavior. Among them, perceived behavioral control was the most notable. A comparative analysis of the differences among stakeholders in the research model shows that "medical administrators” and "nursing staff” have a higher proportion of significant influence effects in various hypotheses, highlighting the critical roles of these two groups in promoting green hospitals. This research policy suggests that the cross-departmental staff in the hospital put forward green innovation ideas, strengthen internal environmental education and management, establish a good incentive system for front-line nursing staff, and implement the sustainable development strategy of the hospital. © 2023 by the authors.

Randomized controlled study protocol: Shensong Yangxin in persistent atrial fibrillation after radiofrequency catheter ablation (SS-ADJUST)

Introduction: Atrial fibrillation (AF) is one of the most common forms of arrhythmia in the clinic. There are about 10 million AF patients in China, of which 1/3 are paroxysmal AF, and the remaining 2/3 are persistent or permanent AF. Long-term AF impairs cardiac function and leads to heart failure and thromboembolism. Moreover, AF increases the risk of mortality and ischemic stroke. Drug therapy and radiofrequency catheter ablation (RFCA) are still the mainstream treatment for AF patients. However, drug therapy has its drawbacks because of the high recurrence rate and side effects. Therefore, the current antiarrhythmic drugs could not meet all the clinical needs of patients with AF. RFCA is superior to antiarrhythmic drugs in maintaining sinus rhythm, improving symptoms and exercise tolerance, and improving quality of life. The role of RFCA in the treatment of persistent AF has gradually been recognized and affirmed. Although RFCA has been progressively used in the treatment of AF, there is still a high recurrence rate of AF after RFCA, especially in patients with persistent AF. Hence, it is meant to solve the high recurrence rate of AF after RFCA. Shensong Yangxin (SSYX) capsule has been proven to treat arrhythmia both in animal studies and clinical research. SSYX capsule could regulate multi-ion channels, improve cardiomyocyte metabolism and regulate autonomic nervous function. In addition, randomized, double-blind, multicenter clinical research indicated that the SSYX capsule exhibited good clinical efficacy in treating ventricular premature beats and paroxysmal AF. However, the effect of SSYX on recurrence after RFCA for patients with persistent AF remains unclear. High-level randomized controlled trials (RCTs) could offer clinicians high-quality evidence regarding the usage of SSYX capsule, especially in persistent AF patients who received RFCA. Hence, the RCTs aim to evaluate the effect of SSYX capsules on the prognosis in patients with persistent AF after RFCA through multicenter, double-blind RCTs. Method(s): This trial will be conducted with a total of 920 participants diagnosed with persistent AF who received RFCA. The participants will be randomized (1:1) into groups receiving either SSYX or Placebo for 1 year. The primary endpoint includes the recurrence of AF within 1 year after RFCA. The secondary outcome measures include changes of AF load at 3 months, 6 months, 9 months, and 1 year after treatment, the time of first atrial flutter/AF, the incidence of cardioversion 1 year after treatment, changes of transthoracic echocardiographic parameters 1 year after treatment, the incidence of stroke and thromboembolism at 6 months and 1 year after treatment, the score of SF-36 within 1 year after treatment. Application: The trial is ongoing. The trial started in September 2019 and recruiting patients. Data collection will be completed after all participants have completed the treatment course and follow-up assessments (expected in 2022, pending COVID-19). Next Steps/Future: The SS-ADJUST study is a randomized control study of TCM in persistent AF after RFCA. It will determine the place of SSYX capsule as a new treatment approach and provide additional and innovative information regarding TCM and the specific use of SSYX in persistent AF after RFCA.

Using Virtual Reality Technology in Biology Education: Satisfaction & Learning Outcomes of High School Students

The use of virtual reality (VR) as a medium for education can contribute to the learning efficiency of students. This study aimed to assess the effectiveness of VR application in advanced biology courses, specifically in enhancing the comprehension and understanding of high school students toward the topic of human organs and other related systems. Four high school teachers and 138 high school students selected from three separate classes participated in this study. To determine the impact of VR education from both teachers' and students' perspectives, learning satisfaction and the effectiveness of instructional material were assessed with questionnaires. We found that from teachers' perspective, VR was an efficient teaching tool that enhanced students' attention and contributed to the improvement of learning outcomes. From the students' perspective, they were willing to use VR instructional material and were satisfied with this learning method. Applying VR technology in the classroom should be encouraged. However, some students identified dizziness as a concern when VR glasses were used for longer periods of time. Therefore, we suggest that VR glasses be limited to 30 minutes of use at a time. © 2023 National Association of Biology Teachers, Inc. All rights reserved.

Covid-19 Vaccination and Covid 19 Infection in Atypical Hemolytic Uremic Syndrome: One Single Center Study in Taiwan

Introduction: Acute kidney injury, microangiopathic hemolytic anemia and thrombocytopenia with multiple organ thrombotic microangiopathy (TMA) are typical characteristic presentation of Atypical hemolytic uremic syndrome(aHUS). Infection, pregnancy, operation, and some medication can be a trigger factor to induce the complement system over activation and induce atypical hemolytic uremic syndrome unstable to a life-threatening condition. Both SARS-CoV-2(Severe Acute Respiratory Syndrome Coronavirus 2) infection and COVID 19 vaccination are reported to be the trigger factors for aHUS. There are no clinical trial enrolled aHUS cases to COVID 19 vaccine or anti SARS-CoV2 agent. Therefore, aHUS became a tough medical issue in this pandemic status. In this study, we evaluate the efficacy and disease activity of aHUS after COVID 19 vaccination. Meanwhile, we analysis the severity of COVID 19 infection in our 21 aHUS cases. Method(s): There are 21 aHUS cases enrolled this study from April 2022 to September 2022. Each cases with regular blood sampling which include hemolysis markers (Hemoglobin, Platelet count, LDH, CH50, haptoglobin, Blood smear), renal function and urine analysis every months. While them had COVID 19 vaccination or COVID 19 infection, the above blood sampling and urine analysis should be followed up two weeks later. Once the aHUS cases became severe condition and need hospitalization, our medical team must visit these cases closely and monitor if any new critical issue happen. We confirmed the serum SARS-CoV-2 Spike IgG and Interferon-gamma (IFNgamma) release assay testing for the vaccination efficacy analysis. Result(s): 21 aHUS cases all had COVID 19 vaccination, 2 cases received 1 dose vaccine, 6 cases received 2 doses vaccine and 13 cases received 3 doses vaccine. Only one case with aHUS unstable after Moderna vaccine injection which is self-limited gradually and didn't need extra dose of anti-complement therapy. Interestingly, this case with stable aHUS disease activity while he switches to Pfizer-BioNTech vaccine as his 2nd dose. The SARS CoV-2 Spike IgG level and IFNgamma level are corelated to the dosage of COVID 19 vaccination, the higher doses with the higher level. The SARS-CoV2 spike IgG and IFNgamma level without lower response to the group with regular anti-C5 treatment. For those complete three dose vaccination cases, mix type of COVID-19 vaccination (AZ/mRNA) with better efficacy trend to fix type of mRNA. During this study period, there are 4 cases with COVID 19 infection. One case (already had 2 doses COVID 19 vaccination) needed hospitalization and improved after remdesivir and dexamethasone treatment who with mild aHUS disease activity progression. Two cases (complete three doses COVID 19 vaccination) with stable aHUS disease activity after Molnupiravir treatment. One case (complete three doses COVID 19 vaccination) refused Molnupiravir treatment and had mild aHUS disease activity progression. Conclusion(s): According to our study, we recommend the aHUS patient to have COVID 19 vaccination and multiple doses are more protective for them. aHUS disease activity should be close monitor especially after COVID 19 vaccination, during COVID 19 infection and after COVID 19 infection. Remdesivir and Molmupiravir are relative safe to use for aHUS cases. No conflict of interestCopyright © 2023

How to Prepare for the Next Pandemic - Investigation of Correlation Between Food Prices and COVID-19 From Global and Local Perspectives

The coronavirus disease (COVID-19) has caused enormous disruptions to not only the United States, but also the global economy. Due to the pandemic, issues in the supply chain and concerns about food shortage drove up the food prices. According to the U.S. Bureau of Labor Statistics, the prices for food increased 4.1% and 3.7% over the year ended in August 2020 and August 2021, respectively, while the amount of annual increase in the food prices prior to the COVID-19 pandemic is less than 2.0%. Previous studies show that such kinds of exogenous disasters, including the 2011 Tohoku Earthquake, 9/11 terrorist attacks, and major infectious diseases, and the resulted unusual food prices often led to subsequent changes in people's consumption behaviors. We hypothesize that the COVID-19 pandemic causes food price changes and the price changes alter people's grocery shopping behaviors as well. To thoroughly explore this, we formulate our analysis from two different perspectives, by collecting data both globally, from China, Japan, United Kingdom, and United States, and locally, from different groups of people inside the US. In particular, we analyze the trends between food prices and COVID-19 as well as between food prices and spending, aiming to find out their correlations and the lessons for preparing the next pandemic. © 2022 IEEE.

Antiviral agents for COVID-19.

In December 2019, the endemic of COVID-19 broke out in Wuhan, China. The disease is highly contagious and quickly spreads at home and abroad, causing great concern. However, there are no definite effective antiviral drugs in clinical use. Given the urgency of the COVID-19 outbreak, based on the diagnosis and treatment recommendation and relavant researches, this article describes the optional antiviral drugs such as remdesivir, oseltamivir, arbidol, lopinavir/ritonavir, ribavirin, and interferon-alpha to provide a reference for treatment of COVID-19.Copyright © 2020 by the Chinese Medical Association.